Caffeine promotes wakefulness via dopamine signaling in Drosophila
Identifieur interne : 000336 ( Main/Exploration ); précédent : 000335; suivant : 000337Caffeine promotes wakefulness via dopamine signaling in Drosophila
Auteurs : Aleksandra H. Nall [États-Unis] ; Iryna Shakhmantsir [États-Unis] ; Karol Cichewicz [États-Unis] ; Serge Birman [France] ; Jay Hirsh [États-Unis] ; Amita Sehgal [États-Unis]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Caffeine is the most widely-consumed psychoactive drug in the world, but our understanding of how caffeine affects our brains is relatively incomplete. Most studies focus on effects of caffeine on adenosine receptors, but there is evidence for other, more complex mechanisms. In the fruit fly
Url:
DOI: 10.1038/srep20938
PubMed: 26868675
PubMed Central: 4751479
Affiliations:
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Nall</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Cell and Molecular Biology Program, Perelman School of Medicine, University of Pennsylvania</institution>, Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shakhmantsir, Iryna" sort="Shakhmantsir, Iryna" uniqKey="Shakhmantsir I" first="Iryna" last="Shakhmantsir">Iryna Shakhmantsir</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Cell and Molecular Biology Program, Perelman School of Medicine, University of Pennsylvania</institution>, Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cichewicz, Karol" sort="Cichewicz, Karol" uniqKey="Cichewicz K" first="Karol" last="Cichewicz">Karol Cichewicz</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Biology, University of Virginia</institution>, Charlottesville, VA 22904,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Birman, Serge" sort="Birman, Serge" uniqKey="Birman S" first="Serge" last="Birman">Serge Birman</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Genes Circuits Rhythms and Neuropathologies, Brain Plasticity Unit, CNRS, PSL Research University</institution>, ESPCI ParisTech, 10 rue Vauquelin, 75005 Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hirsh, Jay" sort="Hirsh, Jay" uniqKey="Hirsh J" first="Jay" last="Hirsh">Jay Hirsh</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Biology, University of Virginia</institution>, Charlottesville, VA 22904,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sehgal, Amita" sort="Sehgal, Amita" uniqKey="Sehgal A" first="Amita" last="Sehgal">Amita Sehgal</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Cell and Molecular Biology Program, Perelman School of Medicine, University of Pennsylvania</institution>, Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania</institution>, Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26868675</idno><idno type="pmc">4751479</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751479</idno><idno type="RBID">PMC:4751479</idno><idno type="doi">10.1038/srep20938</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000188</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000188</idno><idno type="wicri:Area/Pmc/Curation">000187</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000187</idno><idno type="wicri:Area/Pmc/Checkpoint">000112</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000112</idno><idno type="wicri:Area/Ncbi/Merge">001948</idno><idno type="wicri:Area/Ncbi/Curation">001948</idno><idno type="wicri:Area/Ncbi/Checkpoint">001948</idno><idno type="wicri:Area/Main/Merge">000338</idno><idno type="wicri:Area/Main/Curation">000336</idno><idno type="wicri:Area/Main/Exploration">000336</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Caffeine promotes wakefulness via dopamine signaling in <italic>Drosophila</italic></title><author><name sortKey="Nall, Aleksandra H" sort="Nall, Aleksandra H" uniqKey="Nall A" first="Aleksandra H." last="Nall">Aleksandra H. Nall</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Cell and Molecular Biology Program, Perelman School of Medicine, University of Pennsylvania</institution>, Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shakhmantsir, Iryna" sort="Shakhmantsir, Iryna" uniqKey="Shakhmantsir I" first="Iryna" last="Shakhmantsir">Iryna Shakhmantsir</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Cell and Molecular Biology Program, Perelman School of Medicine, University of Pennsylvania</institution>, Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cichewicz, Karol" sort="Cichewicz, Karol" uniqKey="Cichewicz K" first="Karol" last="Cichewicz">Karol Cichewicz</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Biology, University of Virginia</institution>, Charlottesville, VA 22904,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Birman, Serge" sort="Birman, Serge" uniqKey="Birman S" first="Serge" last="Birman">Serge Birman</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Genes Circuits Rhythms and Neuropathologies, Brain Plasticity Unit, CNRS, PSL Research University</institution>, ESPCI ParisTech, 10 rue Vauquelin, 75005 Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hirsh, Jay" sort="Hirsh, Jay" uniqKey="Hirsh J" first="Jay" last="Hirsh">Jay Hirsh</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Biology, University of Virginia</institution>, Charlottesville, VA 22904,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sehgal, Amita" sort="Sehgal, Amita" uniqKey="Sehgal A" first="Amita" last="Sehgal">Amita Sehgal</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Cell and Molecular Biology Program, Perelman School of Medicine, University of Pennsylvania</institution>, Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania</institution>, Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Caffeine is the most widely-consumed psychoactive drug in the world, but our understanding of how caffeine affects our brains is relatively incomplete. Most studies focus on effects of caffeine on adenosine receptors, but there is evidence for other, more complex mechanisms. In the fruit fly <italic>Drosophila melanogaster</italic>, which shows a robust diurnal pattern of sleep/wake activity, caffeine reduces nighttime sleep behavior independently of the one known adenosine receptor. Here, we show that dopamine is required for the wake-promoting effect of caffeine in the fly, and that caffeine likely acts presynaptically to increase dopamine signaling. We identify a cluster of neurons, the paired anterior medial (PAM) cluster of dopaminergic neurons, as the ones relevant for the caffeine response. PAM neurons show increased activity following caffeine administration, and promote wake when activated. Also, inhibition of these neurons abrogates sleep suppression by caffeine. While previous studies have focused on adenosine-receptor mediated mechanisms for caffeine action, we have identified a role for dopaminergic neurons in the arousal-promoting effect of caffeine.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Penetar, D" uniqKey="Penetar D">D. Penetar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alhaider, I A" uniqKey="Alhaider I">I. A. Alhaider</name></author><author><name sortKey="Aleisa, A M" uniqKey="Aleisa A">A. M. Aleisa</name></author><author><name sortKey="Tran, T T" uniqKey="Tran T">T. T. Tran</name></author><author><name sortKey="Alzoubi, K H" uniqKey="Alzoubi K">K. H. Alzoubi</name></author><author><name sortKey="Alkadhi, K A" uniqKey="Alkadhi K">K. A. Alkadhi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fredholm, B B" uniqKey="Fredholm B">B. B. 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Pech</name></author><author><name sortKey="Pooryasin, A" uniqKey="Pooryasin A">A. Pooryasin</name></author><author><name sortKey="Birman, S" uniqKey="Birman S">S. Birman</name></author><author><name sortKey="Fiala, A" uniqKey="Fiala A">A. Fiala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, S" uniqKey="Lin S">S. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agrawal, T" uniqKey="Agrawal T">T. Agrawal</name></author><author><name sortKey="Hasan, G" uniqKey="Hasan G">G. Hasan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ribeiro, J A" uniqKey="Ribeiro J">J. A. Ribeiro</name></author><author><name sortKey="Sebastiao, A M" uniqKey="Sebastiao A">A. M. Sebastião</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcpherson, P S" uniqKey="Mcpherson P">P. S. McPherson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Nall, Aleksandra H" sort="Nall, Aleksandra H" uniqKey="Nall A" first="Aleksandra H." last="Nall">Aleksandra H. Nall</name></noRegion><name sortKey="Cichewicz, Karol" sort="Cichewicz, Karol" uniqKey="Cichewicz K" first="Karol" last="Cichewicz">Karol Cichewicz</name><name sortKey="Hirsh, Jay" sort="Hirsh, Jay" uniqKey="Hirsh J" first="Jay" last="Hirsh">Jay Hirsh</name><name sortKey="Sehgal, Amita" sort="Sehgal, Amita" uniqKey="Sehgal A" first="Amita" last="Sehgal">Amita Sehgal</name><name sortKey="Sehgal, Amita" sort="Sehgal, Amita" uniqKey="Sehgal A" first="Amita" last="Sehgal">Amita Sehgal</name><name sortKey="Shakhmantsir, Iryna" sort="Shakhmantsir, Iryna" uniqKey="Shakhmantsir I" first="Iryna" last="Shakhmantsir">Iryna Shakhmantsir</name></country><country name="France"><noRegion><name sortKey="Birman, Serge" sort="Birman, Serge" uniqKey="Birman S" first="Serge" last="Birman">Serge Birman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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